Malar rash fixed erythema, flat or raised, over the malar eminences, tending to spare the nasolabial folds 2. The recent used diagnostic criteria widely used for sle is 2015 acr slicc revised criteria for diagnosis of systemic lupus erythematosus which is based on point systems. Death data were prospectively collected or acquired through probabilistic linkage to vital statistics registries. Objective sle is traditionally classified using the american college of rheumatology acr criteria. Systemic lupus diagnostic criteria slicc calculator. The american college of rheumatology has 11 classification criteria for lupus.
Derivation and validation of the systemic lupus international. This study examined large cohorts of subjects with sle and incomplete lupus erythematosus ile to compare the impact of acr and slicc criteria. Apr 27, 2016 healthdayneither the american college of rheumatology acr nor the systemic lupus international collaborating clinics slicc criteria distinguishes patients with subacute cutaneous lupus. The systemic lupus international collaborating clinics slicc classification criteria was composed in order to diagnose sle earlier.
Sleslicconly subjects gained criteria through low complement levels 81178, 45. Indeed, it is the diversity of presentation, accumulation of manifestations over time, and undulating disease course that challenge the most astute of clinicians. The systemic lupus international collaborating clinics slicc. The slicc criteria use a combination of clinical and immunologic features to determine whether a patient has sle. Patients must have a total of four criteria, with at least one clinical feature and one immunologic feature. Discoid rash raised erythematous patches with keratotic scaling, follicular plugging, and atrophic scarring 3. Jan 10, 2015 in 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc 12 to classify systemic lupus erythematosus sle. Use of slicc criteria in a large, diverse lupus registry. Sep 17, 2014 the main strength of this study was the comparison between the acr and the new slicc criteria, in a jsle population at different moments of followup. The 2012 revised slicc criteria for classification of. Slicc 12, the new set of criteria established in 2012 to. Calculate is a nextgeneration clinical calculator and decision support tool freely available to the medical community.
Updates on lupus 2017 urmc university of rochester. Wallace,8 ola nived,9 gunnar sturfelt,9 rosalind ramseygoldman,10 sangcheol bae,11. Sle or lupus for short is a multisystem, autoimmune disease, involving. The patients were enrolled at the lupus clinic in a single center in southwest roanoke, 118 virginia.
In the slicc system, a patient must meet at least four criteria, including at least one abnor mal clinical criterion and one abnormal immunologic criterion, or. To compare patients with systemic lupus erythematosus sle from different centers with respect to demographics and systemic lupus international collaborating clinicsamerican college of rheumatology damage index sliccacr di scores, and to assess whether the sliccacr di changed over time, and whether initial di scores were related to outcome. Clinical and serological discordance in the systemic lupus. Pdf new classification criteria for systemic lupus erythematosus. International collaborating clinics classification criteria to patients in a regional swedish systemic lupus erythematosus register anna ighe1, orjan dahlstrom2, thomas skogh1 and christopher sjowall1 abstract introduction.
Objective to develop new classification criteria for systemic lupus erythematosus sle jointly supported by the european league against rheumatism eular and the american college of rheumatology. Slicc classification criteria for systemic lupus erythematosus. In contrast to the acr criteria, there are newer criteria called the slicc systemic lupus international collaborating clinics classification. Pdf cutaneous manifestations of systemic lupus erythematosus. Based on sensitivity and specificity slicc 12 is best for adult sle. We suggest combining antimalarial treatment with mepacrine and hydroxychloroquine. Based on sensitivity and specificity slicc12 is best for adult sle. Use of slicc criteria in a large, diverse lupus registry enables sle. Altmetric use of slicc criteria in a large, diverse lupus. However, they have become widely used as diagnostic criteria in clinical situations. Patients may be labelled as systemic lupus erythematosus sle in their medical records, when in fact they have cutaneous lupus. American college of rheumatology classification criteria for. Sliccacr criteria dont id severe internal disease in scle.
Merging malar rash and photosensitivity into one item in slicc12 is the main reason for patients the majority 11, 2229 15, 57 12. Application of the 2012 systemic lupus international. The systemic lupus international collaborating clinicsamerican college of rheumatology slicc acr damage index for systemic lupus erythematosus international comparison j rheumatol, 27 2 2000, pp. Systemic lupus erythematosus combines basic science with clinical science to provide a translational treatment of the disease and is a useful reference for specialists in the diagnosis and management of patients with sle, a tool for measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference. The systemic lupus international collaborating clinics slicc recently validated an alternative system. The slicc criteria for sle classification requires. The diagnostic accuracies of the 2012 slicc criteria and the. Positive ana or positive antidsdna revised 2015 criteria endorsed by the acr combines 1997 criteria and slicc criteria 4 out of 16 points, definite sle 3 out of 16 points. Clinical and serological discordance in the systemic lupus erythematosus international collaborating clinics slicc cohort murray b. Pdf 2015 acrslicc revised criteria for diagnosis of.
If a patient meets at least four criteria, lupus can be diagnosed with 95% specificity and 85% sensitivity. Their work included both a derivation and a validation of the new set of criteria as well as of acr97. Slicc criteria through biopsyproven lupus nephritis with positive ana or antidsdna. Pdf incomplete systemic lupus erythematosus what remains. How is systemic lupus international collaborating clinics abbreviated. With rare exception, the unifying laboratory abnormality is. The 2012 systemic lupus international collaborating clin ics slicc classification criteria addressed many of these issues. The 2012 systemic lupus international collaborating clinics slicc classification criteria addressed many of these issues 9. Study evaluates slicc12 classification criteria for lupus. Higher interferon score and normal complement levels may.
Systemic lupus erythematosus, interferon score, complement, autoinflammation, autoimmunity, patients stratification introduction systemic lupus erythematosus systemic lupus erythematosus sle is a multisystem inflammatory and autoimmune disorder and it is characterized by a wide spectrum of clinical manifestations. However, our patient met the acr criteria for sle which has a sensitivity of 85% and specificity of 95%11 as he had arthralgias, pleural and pericardial effusions, lymphopenia and raised antidsdna, and met 5 out of 11 criteria according to newer systemic lupus international collaboration clinics criteria slicc criteria due to decreased. Joining the dots for patients with systemic lupus erythematosus. This systemic lupus diagnostic criteria slicc calculator helps the classification and diagnosis of sle based on clinical and immunological criteria. Gladman 1, nicole anderson 1 and systemic lupus erythematosus international collaborating clinics slicc 2, 1 division of rheumatology, university of toronto, toronto western hospital. Thus, slicc 12 criteria were applied to confirmed sle cases in our regional sle register as well as to individuals. We included 56 confirmed sle cases meeting the 1982 acr criteria. Subjects who gain sle classification through slicc criteria exhibit heterogeneous disease, including potential. The systemic lupus international collaborating clinics. An abstract of the article sliccacr damage index in systemic lupus erythematosus sle patients with long disease duration is presented. Objectives remission in systemic lupus erythematosus sle is defined through a combination of clinical sle disease activity index csledai0, physicians global assessment pga slicc acr damage index. The high initial score at diagnosis significantly showed an increased damage over time. The use of slicc and acr criteria to correctly label patients.
Systemic lupus erythematosus sle is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. In this jsle population, the slicc criteria performed best in terms of sensitivity at both observation periods. Slicc stands for systemic lupus international collaborating clinics. Slicc classification criteria may provide useful guidance for the diagnosis.
Im curious to know why there is no mention of the slicc criteria in the article. Slicc is defined as systemic lupus international collaborating clinics somewhat frequently. Aim to determine the prevalence of american college of rheumatology acr and systemic lupus international collaborating clinics slicc. Jul 14, 2014 however, they do not include the updated and more extended variables defined in the slicc criteria. Jun 16, 2016 the most recent criteria were published by the systemic lupus international collaborating clinics slicc in 2012. Systemic lupus international collaborating clinics slicc criteria.
Diagnostic criteria for systemic lupus erythematosus. Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often. The american college of rheumatology acr classification criteria for lupus and systemic lupus international collaborating clinics slicc criteria are designed to classify disease. Systemic lupus international collaborating clinics classification criteria for systemic lupus erythematosus michelle petri, 1anamaria orbai, graciela s.
The present study is the first to evaluate the performance of slicc 12 in an adult european study population. Innovative ways to combine rituximab with benlysta. The systemic lupus international collaborating clinics slicc network, devoted to clinical research in sle, presented a new set of classification criteria in 2012 slicc 12 based on the evaluation of almost 1,400 patient scenarios. Systemic lupus erythematosus is a multiorgan system autoimmune disease with clinical and serological heterogeneity.
Mucocutaneous and neuropsychiatric manifestations were added, as were hypocomplementemia and new antiphospholipid. At least four of slicc criteria, including at least one clinical criterion and one immunologic. Slicc criteria for sle slicc classification criteria for sle. The 2012 slicc criteria classify juvenile patients earlier than the 1997 acr criteria. Slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Derivation and validation of systemic lupus international. In 2012, the systemic lupus international collaborating clinics slicc network presented a new set of criteria slicc. A list of items considered to reflect damage in sle was generated through a nominal group from the systemic lupus international collaborating clin ics slicc and the american college of rheumatology diagnostic and therapeutic criteria committee.
Background systemic lupus erythematosus sle is a disease with an autoimmune origin, which occurs nine times more often in women than in men, and. Performance of the 2012 systemic lupus international collaborating. Slicc systemic lupus international collaborating clinics. Pdf diagnostic criteria for systemic lupus erythematosus. Unlike the acr criteria, the slicc criteria are intended for diagnostic purposes. Oct 22, 2015 pdf version slicc classification criteria for sle amith balachandran, department of anaesthesia, cmc vellore, and ashish jacob mathew, assistant professor, department of rheumatology, cmc, vellore. Discoid rash erythematous raised patches with adherent keratotic scaling and follicular. The formulation of initial criteria for sle was first proposed by the american college of rheumatology and appeared in 1971. All patients met the 2009 systemic lupus international collaborating clinic slicc revised 119 american college of rheumatology acr diagnostic criteria for sle. Objective the systemic lupus international collaborating clinics slicc group revised and validated the american college of rheumatology acr systemic lupus erythematosus sle classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of sle. The new slicc criteria provide a comprehensive alternative for use in clinical care and research, offering a more differentiated picture of the autoimmune processes in lupus patients.
Collaboration of the systemic lupus international collaborating clinics slicc and the canadian network for improved outcomes in systemic lupus canios investigator groups us, canada, england, scotland, iceland, sweden, south korea. Acute cutaneous lupus, including lupus malar rash, bullous lupus, toxic epidermal necrolysis variant of systemic lupus erythematosus, photosensitive lupus rash, maculopapular lupus rash, or subacute cutaneous lupus psoriaform or annular polycyclic lesions or both 2. Pdf performance of the new slicc classification criteria. Performance of the new slicc classification criteria in. Gut microbiota in human sle and a mouse model of lupus.
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